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KMID : 1177320210240020052
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Korean Journal of Schizophrenia Research
2021 Volume.24 No. 2 p.52 ~ p.59
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Effect of Delayed Clozapine Initiation on Acute Treatment Response in Treatment-Resistant Schizophrenia
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Yang So-Yung
Choi Jung-Kyu
Park Sun-Young
Park Jae-Sub
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Abstract
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Objectives: Recent studies have reported that delayed initiation of clozapine can affect clinical response in patients with treatment- resistant schizophrenia (TRS). This study aimed to explore the relationship between delayed initiation of clozapine and acute treatment response.
Methods: Sixty-five inpatients with TRS who started clozapine for the first time were included through a retrospective chart review.
Acute treatment response was defined as a 30% reduction in the Positive and Negative Syndrome Scale score or a Clinical Global Impression of Improvement score of 1 (very much improved) or 2 (much improved) at 4 weeks after initiating clozapine.
Results: After meeting the TRS criteria, the mean delay for initiating clozapine was approximately 13.8 months. The delay was shorter in patients who showed a better response to clozapine in logistic regression analysis (p=0.037).
Conclusion: Our findings suggest that reducing the delay in initiating clozapine increases the effectiveness of clozapine in patients with TRS.
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KEYWORD
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Clozapine, Treatment delay, Treatment resistant schizophrenia, Treatment response
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